Henderson Laboratory

Selected Publications

Cornblath EJ, Li HL, Changolkar L, Zhang B, Brown HJ, Gathagan RJ, Olufemi MF, Trojanowski JQ, Bassett DS, Lee VYM, Henderson MX. 2021. Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor. Sci Adv 7(24):eabg6677.

Henderson MX, Changolkar L, Trojanowski JQ, Lee VMY. In press. LRRK2 kinase activity does not alter cell-autonomous tau pathology development in primary neurons. J Parkinson’s Dis.

Henderson MX, Sedor S, McGeary I, Cornblath EJ, Peng C, Riddle DM, Li HL, Zhang B, Brown H, Olufemi MF, Bassett DS, Trojanowski JQ, Lee VMY. 2020. Glucocerebrosidase activity modulates neuronal vulnerability to α-synuclein pathology. Neuron 105:1–15.

Henderson MX, Covell DJ, Chung CHY, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden K, Lee VMY, Luk K. 2020. Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson’s disease. Neurobiol Dis 136:104712.

Henderson MX, Sengupta M, Trojanowski JQ, Lee VMY. 2019. Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease. Acta Neuropathol Commun 7(1):183.

Henderson MX, Cornblath EJ, Darwich A, Zhang B, Brown H, Gathagan H, Sandler R, Bassett DS, Trojanowski JQ, Lee VMY. 2019. Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis. Nat Neuro 22:1248–1257.
Reviewed in:
Kuhl, E. 2019.
Connectomics of neurodegeneration. Nat Neuro 22:1200–1202.
Lempriere S. 2019. Connectivity and vulnerability determine α-synuclein spread. Nat Rev Neurol.  

Henderson MX, Trojanowski JQ, Lee VMY. 2019. α-Synuclein pathology in Parkinson’s disease and related α-synucleinopathies. Neurosci Lett 709:134316.

Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski, JQ, Lee VMY. 2019. LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic animals. Acta Neuropathol Commun 7:28.

Henderson MX, Peng C, Trojanowski, JQ, Lee VMY. 2018. LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons. Acta Neuropathol Commun 6:45.

Henderson MX, Chung CH-Y, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski, JQ, Lee VMY. 2017. Unbiased proteomics of early Lewy body formation model implicates active microtubule affinity-regulating kinases (MARKs) in synucleinopathies. J Neurosci 37(24):5870–5884.

Henderson MX*, Wirak GS*, Zhang YQ, Dai F, Ginsberg SD, Dolzhanskaya N, Staropoli JF, Nijssen PC, Lam TT, Roth AF, Davis NG, Dawson G, Velinov M, Chandra SS. 2016. Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathol 131(4):621–637.

Zhang Y*, Henderson MX*, Colangelo CM, Ginsberg S, Bruce C, Wu T, Chandra SC. 2012. Identification of CSPα clients reveals a role in dynamin 1 regulation. Neuron 74:136–150. 
Reviewed in: Sheng J, Wu L. 2012. Cysteine string protein α: A new role in vesicle recycling. Neuron 74:6–8.

*These authors contributed equally to this work